Page 73 - Fisica In Medicina n° 1/2017

ResultsMean BM number was 2 (range 1-8), median Gross Tumour Volume Brain metastases (GTVBM) and median Planning Target Volume (PTV) were 1.11cc (range 0.01-57.2cc) and 2.96cc (range 0.45-77.45cc), respectively. The median follow-up was 8 months (range 3-25). A good rate of acute toxicity profile was documented. We observed a complete radiological response in 15.3% of BM, a partial response in 36.5%, a stable disease in 28.2% and a BM progression in 5.9%; while in 14.1% of BM, radiological response was not evaluated due to patients’ expire and 3 patients (with 4 brain metastases) were lost during follow up. A Central Nervous System progression was reported in 17 patients. No cases of radionecrosis were found during follow up.ConclusionVMAT-FFF approach seemed to be well tolerated during preliminary evaluation. We also observed promising results with 80% of response rate and BM control after this radiosurgical and stereotactic hypofractionated linac-based approach. Long follow-up is needed to definitively establish the tolerability and the significant impact of stereotactic treatment using VMAT and FFF in brain metastases setting.^Äëíê~Åí=jÉÇáÅá= =64