Page 72 - Fisica In Medicina n° 1/2017

^Äëíê~Åí=jÉÇáÅá= =Feasibility of VMAT and Flattening Filter Free delivery for brain metastases patients treated by stereotactic Linac-Based approachN. GIAJ-LEVRA1, U. TEBANO1,2, A. FIORENTINO1, R. MAZZOLA1, F. RICCHETTI1, S. FERSINO1, G. SICIGNANO1, S. NACCARATO1, R. RUGGIERI1, F. ALONGI11Radiation Oncology Division, Sacro Cuore Don Calabria Hospital, Cancer Care Center, Negrar-Verona, Italy2Radiation Oncology Division, University of Padua, ItalyAimStereotactic radiosurgery (SRS) and Hypofractionated stereotactic radiotherapy (HSRT) are technical approaches able to guarantee high conformity and excellent results in terms of local control and tolerability in brain metastases (BM). Aim of the present preliminary study is to evaluate the feasibility and impact of Volumetric Modulated Arc Therapy (VMAT) with Flattening Filter Free (FFF) photon beams approach to hypofractionated treatments in patients with a limited number of brain metastases.Materials and MethodsFrom April 2014 to February 2016, 45 patients (23 male and 22 female) with 89 BM were treated with SRS or HSRT and VMAT-FFF approach. Patients eligible showed a number of brain metastases < 5, size ≤ 30mm, Karnosky Performance Status ≥ 80 and a life expectancy over 3 months. All patients were stratified according to Graded Prognostic Assessment (GPA). Dose prescription was assessed according to BM volume and anatomical position (i.e. eloquent area). Median dose prescription was 25Gy in SRS (range 18-25Gy) and 25Gy in HSRT (range 21-35Gy) with a median number of 3 sessions (range 3-5). During treatment, to prevent neurological symptoms, a corticosteroid therapy was prescribed. Patients were evaluated with MRI after 45-60 days by the end of radiation treatment, then every 3 months.63